The most common and most likely answer to this crossword clue is the 10 letter word MISANDRIST
I've seen this crossword clue in The Guardian
M
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S
A
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More clues leading to the result MISANDRIST
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MISANDRIST mean?
MISANDRIST noun- One who professes misandry; a hater of men.
- Exhibiting or pertaining to misandry: hating or prejudiced against men.