Cryptic crossword clue
One thinks about industrial city familiarly after church 8

The most common and most likely answer to this crossword clue is the 8 letter word CEREBRUM

C
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R
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B
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Buddy explains!

The straight part
We know that "One thinks" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one thinks = cerebrum.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CEREBRUM mean?

CEREBRUM noun
  1. The upper part of the brain, which is divided into the two cerebral hemispheres. In humans it is the largest part of the brain and is the seat of motor and sensory functions, and the higher mental functions such as consciousness, thought, reason, emotion, and memory.

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