The most common and most likely answer to this crossword clue is the 7 letter word OPPOSER
I've seen this crossword clue in The Times
O
P
P
O
S
E
R
More clues leading to the result OPPOSER
- One who takes on work with model
- One resisting old person’s first question
- Work given to model is a con
- One against giving work to model?
- One who resists work with model
- One who is against work has a problem
- You can't expect him to propose, in other words
- Is he against work? That's the question
- Operation Puzzle protestor?
Buddy explains!
The straight part
We know that "One who takes on" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one who takes on = opposer.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.