Cryptic crossword clue
One with sixteen wheels carrying international concerns 9

The most common and most likely answer to this crossword clue is the 9 letter word ANXIETIES

I've seen this crossword clue in The Guardian
A
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X
I
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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does ANXIETIES mean?

ANXIETIES noun
  1. An unpleasant state of mental uneasiness, nervousness, apprehension and obsession or concern about some uncertain event.
  2. An uneasy or distressing desire (for something).
  3. A state of restlessness and agitation, often accompanied by a distressing sense of oppression or tightness in the stomach.

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