Cryptic crossword clue
One would become crazy losing this game 7

The most common and most likely answer to this crossword clue is the 7 letter word MARBLES

I've seen this crossword clue in The Times
M
A
R
B
L
E
S

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The straight part
We know that "game" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case game = marbles.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MARBLES mean?

MARBLES noun
  1. A rock of crystalline limestone.
  2. (games) A small ball, usually of glass or ceramic.
  3. An artwork made from marble.
MARBLES verb
  1. To cause (something to have) the streaked or swirled appearance of certain types of marble, for example by mixing viscous ingredients incompletely, or by applying paint or other colorants unevenly.
  2. To get or have the streaked or swirled appearance of certain types of marble, for example due to the incomplete mixing of viscous ingredients, or the uneven application of paint or other colorants.
  3. To cause meat, usually beef, pork, or lamb, to be interlaced with fat so that its appearance resembles that of marble.
  4. (of meat, especially beef) To become interlaced with fat; (of fat) to interlace through meat.
  5. (by extension) To lace or be laced throughout.
MARBLES noun
  1. Any of several children's games played with small balls (made of marble or more commonly glass).
  2. (usually in a limited number of expressions) Sanity.
  3. Bits of rolled-up rubber shed by the tires of race cars that accumulate at the edges of the track, especially at the corners.

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