Cryptic crossword clue
One’s gutted to lose these pubs, cut through by a road 7

The most common and most likely answer to this crossword clue is the 7 letter word INNARDS

I
N
N
A
R
D
S


Buddy explains!

The straight part
We know that "one is gutted to lose these" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one is gutted to lose these = innards.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INNARDS mean?

INNARDS noun
  1. Entrail; gut; intestine.
INNARDS noun
  1. The internal organs of a human or animal; especially viscera, intestines.
  2. The inner workings of something; the insides or guts.

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