Cryptic crossword clue
One’s picked up a rather unreal loss of voice 7

The most common and most likely answer to this crossword clue is the 7 letter word APHONIA

A
P
H
O
N
I
A

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The straight part
We know that "loss of voice" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case loss of voice = aphonia.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does APHONIA mean?

APHONIA noun
  1. Loss of voice; the inability to speak.

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