Cryptic crossword clue
One’s up after six, in disreputable club causing conflict 8

The most common and most likely answer to this crossword clue is the 8 letter word DIVISIVE

I've seen this crossword clue in The Daily Telegraph
D
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V
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Buddy explains!

The straight part
We know that "causing conflict" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case causing conflict = divisive.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DIVISIVE mean?

DIVISIVE adjective
  1. Having a quality that divides or separates

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