Cryptic crossword clue
Oops, Tories so affected by bodily weakness! 12

The most common and most likely answer to this crossword clue is the 12 letter word OSTEOPOROSIS

I've seen this crossword clue in The Guardian
O
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Buddy explains!

The straight part
We know that "bodily weakness" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case bodily weakness = osteoporosis.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does OSTEOPOROSIS mean?

OSTEOPOROSIS noun
  1. A disease, occurring especially in women following menopause, in which the bones become extremely porous and are subject to fracture.

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