Cryptic crossword clue
Open ballot box, causing upset 8

The most common and most likely answer to this crossword clue is the 8 letter word OVERTURN

I've seen this crossword clue in Financial Times
O
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Buddy explains!

The straight part
We know that "upset" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case upset = overturn.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does OVERTURN mean?

OVERTURN noun
  1. A turning over or upside-down; inversion.
  2. The overturning or overthrow of some institution or state of affairs; ruin.
OVERTURN verb
  1. To turn over, capsize or upset.
  2. To overthrow or destroy.
  3. To reverse (a decision); to overrule or rescind.
  4. To diminish the significance of a previous defeat by winning; to make a comeback from.

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