Cryptic crossword clue
Opposition regularly says “guys”: unknown Yankee interrupts 6

The most common and most likely answer to this crossword clue is the 6 letter word SYZYGY

I've seen this crossword clue in The Guardian
S
Y
Z
Y
G
Y


Buddy explains!

The straight part
We know that "Opposition" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case opposition = syzygy.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SYZYGY mean?

SYZYGY noun
  1. An alignment of three celestial bodies (for example, the Sun, Earth, and Moon) such that one body is directly between the other two, such as occurs at an eclipse.
  2. An archetypal pairing of contrasexual opposites, symbolizing the communication of the conscious and unconscious minds.
  3. A relation between generators of a module.
  4. The fusion of some or all of the organs.
  5. The association of two protozoa end-to-end or laterally for the purpose of asexual exchange of genetic material.
  6. The pairing of chromosomes in meiosis.

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