Cryptic crossword clue
Order great changes, going in a bad direction 10

The most common and most likely answer to this crossword clue is the 10 letter word RETROGRADE

I've seen this crossword clue in The Guardian
R
E
T
R
O
G
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A
D
E


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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does RETROGRADE mean?

RETROGRADE adjective
  1. Directed backwards, retreating; reverting, especially to an inferior state, declining; inverse, reverse; movement opposite to normal or intended motion, often circular motion.
  2. Counterproductive to a desired outcome.
  3. (of a body orbiting another) In the opposite direction to the orbited body's spin.
  4. Describing a metamorphic change resulting from a decreasing pressure or temperature.
  5. (by extension, of a person) A person who opposes social reforms, favoring the maintenance of the status quo, conservative.
RETROGRADE noun
  1. A degenerate person.
  2. The reversal of a melody so that what is played first in the original melody is played last and what is played last in the original melody is played first.
RETROGRADE verb
  1. To move backwards; to recede; to retire; to decline; to revert.
  2. To show retrogradation.

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