The most common and most likely answer to this crossword clue is the 5 letter word LIVER
L
I
V
E
R
More clues leading to the result LIVER
- Offal, small portion with top sliced off
- Organ having an audience — introduction to recital
- Being put at risk by too much booze
- Organ in Yorkshire village packed up
- Vital organ — survivor?
- Organ — one breathing?
- Meat: slice trimmed on top
- Hungry boy denied nothing gets meat
- Reddish-brown uniform Yankee removed
- Organ of bird seen in northern city
Buddy explains!

The straight part
We know that "Organ" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case organ = liver.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does LIVER mean?
LIVER noun- A large organ in the body that stores and metabolizes nutrients, destroys toxins and produces bile. It is responsible for thousands of biochemical reactions.
- This organ, as taken from animals used as food.
- A dark brown colour, tinted with red and gray, like the colour of liver.
- Of the colour of liver (dark brown, tinted with red and gray).
- Someone who lives (usually in a specified way).