Cryptic crossword clue
Organic group manufactured from clay … 4

The most common and most likely answer to this crossword clue is the 4 letter word ACYL

I've seen this crossword clue in The Guardian
A
C
Y
L

Buddy explains!

The straight part
We know that "Organic group" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case organic group = acyl.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ACYL mean?

ACYL noun
  1. Any of class of organic radicals, RCO-, formed by the removal of a hydroxyl group from a carboxylic acid.

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