Cryptic crossword clue
Orphan has this hungry child’s affliction 4

The most common and most likely answer to this crossword clue is the 4 letter word NOMA

N
O
M
A

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The straight part
We know that "hungry child’s affliction" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case hungry child’s affliction = noma.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NOMA mean?

NOMA noun
  1. A gangrenous disease leading to tissue destruction of the face, especially the mouth and cheek.

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