Cryptic crossword clue
Orthodox duke replaced by Poles with changes afoot? 12

The most common and most likely answer to this crossword clue is the 12 letter word TRANSITIONAL

I've seen this crossword clue in The Times
T
R
A
N
S
I
T
I
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A
L

Buddy explains!

The straight part
We know that "with changes afoot" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case with changes afoot = transitional.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TRANSITIONAL mean?

TRANSITIONAL adjective
  1. Of, or relating to a transition
  2. Temporary; pending the implementation of something new

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