Cryptic crossword clue
Our sister is transformed by a thousand cosmetic products 12

The most common and most likely answer to this crossword clue is the 12 letter word MOISTURISERS

I've seen this crossword clue in The Daily Telegraph
M
O
I
S
T
U
R
I
S
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S

Buddy explains!

The straight part
We know that "cosmetic products" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case cosmetic products = moisturisers.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MOISTURISERS mean?

MOISTURISERS noun
  1. Something that causes moisture or a a condition of wetness; something that makes things moist.
  2. Moisturising cream, emollient.

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