Cryptic crossword clue
Out-and-out lies oddly cause resentment 6

The most common and most likely answer to this crossword clue is the 6 letter word RANKLE

I've seen this crossword clue in The Times
R
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K
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Buddy explains!

The straight part
We know that "cause resentment" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case cause resentment = rankle.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RANKLE mean?

RANKLE verb
  1. To cause irritation or deep bitterness.
  2. To fester.

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