Cryptic crossword clue
Out of control city mess affecting an entire body 8

The most common and most likely answer to this crossword clue is the 8 letter word SYSTEMIC

I've seen this crossword clue in The Guardian
S
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Buddy explains!

The straight part
We know that "affecting an entire body" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case affecting an entire body = systemic.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SYSTEMIC mean?

SYSTEMIC adjective
  1. Embedded within and spread throughout and affecting a whole system, group, body, economy, market, or society.
  2. Pertaining to an entire organism.

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