Cryptic crossword clue
Outer layer of eye's clear, going around 6

The most common and most likely answer to this crossword clue is the 6 letter word SCLERA

S
C
L
E
R
A

Buddy explains!

The straight part
We know that "Outer layer of eye" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case outer layer of eye = sclera.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SCLERA mean?

SCLERA noun
  1. The white of the eye. It is the tough outer coat of the eye that covers the eyeball except for the cornea.

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