Cryptic crossword clue
Overly fearful artist and leader are confined in home 8

The most common and most likely answer to this crossword clue is the 8 letter word PARANOID

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Buddy explains!

The straight part
We know that "Overly fearful" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case overly fearful = paranoid.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PARANOID mean?

PARANOID noun
  1. Someone suffering from paranoia
PARANOID adjective
  1. Of, related to, or suffering from paranoia
  2. Exhibiting extreme and irrational fear or distrust of others

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