Cryptic crossword clue
Overrule patient loathing leaving hospital 10

The most common and most likely answer to this crossword clue is the 10 letter word INVALIDATE

I've seen this crossword clue in The Daily Telegraph
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Buddy explains!

The straight part
We know that "Overrule" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case overrule = invalidate.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

Crossword Answer definitions

INVALIDATE verb
  1. To make invalid. Especially applied to contract law.

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