The most common and most likely answer to this crossword clue is the 5 letter word UPEND
U
P
E
N
D
More clues leading to the result UPEND
- Drastically affect completed objective
- Overturn university marker over delta
- Leading by goal, change things drastically
- Overturn northern result
- Seconds left to postpone trip
- Overturn winning goal
- Sacrifice bishop for pawn in trap, gaining turn
- Duo spy Wendy shedding clothes to stand on head
- Winning back position the other way
- Knock over raised object
Buddy explains!

The straight part
We know that "Overthrow" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case overthrow = upend.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does UPEND mean?
UPEND verb- To end up; to set on end.
- To tip or turn over.
- To destroy, invalidate, overthrow, or defeat.