The most common and most likely answer to this crossword clue is the 6 letter word CREAMS
I've seen this crossword clue in The Times
C
R
E
A
M
S
Buddy explains!
The straight part
We know that "Overwhelms" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case overwhelms = creams.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does CREAMS mean?
CREAMS noun- The butterfat/milkfat part of milk which rises to the top; this part when separated from the remainder.
- A yellowish white colour; the colour of cream.
- Frosting, custard, creamer or another substance similar to the oily part of milk or to whipped cream.
- The best part of something.
- A viscous aqueous oil/fat emulsion with a medicament added, used to apply that medicament to the skin. (compare with ointment)
- Semen.
- The chrism or consecrated oil used in anointing ceremonies.
- To puree, to blend with a liquifying process.
- To turn a yellowish white colour; to give something the color of cream.
- To obliterate, to defeat decisively.
- To ejaculate (used of either gender).
- To ejaculate in (clothing).
- To rub, stir, or beat (butter) into a light creamy consistency.
- To skim, or take off by skimming, as cream.
- To take off the best or choicest part of.
- To furnish with, or as if with, cream.
- To gather or form cream.