Cryptic crossword clue
Ozzy Osbourne’s home taking LSD in mad cocktail 8

The most common and most likely answer to this crossword clue is the 8 letter word MIDLANDS

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "Ozzy Osbourne’s home" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case ozzy osbourne’s home = midlands.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MIDLANDS mean?

MIDLANDS noun
  1. The region of a country not near the borders; the interior.

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