The most common and most likely answer to this crossword clue is the 4 letter word ODDS
I've seen this crossword clue in Financial Times
O
D
D
S
More clues leading to the result ODDS
- What bookie offers ultimately to defraud bad betters
- Detective goes after taking too many chances
- However, those may be evens!
- Nothing’s accepted in supplements, causing dispute
- Chances opening items from old and desperately dusty shelves
- What may, paradoxically, be evens?
- Chances of dying do soar at the front
- Old and capacious cups for price
- Price of round and capacious cups?
- Chances of good kids getting half cut
Buddy explains!

The straight part
We know that "P_O_A_I_I_Y?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case p_o_a_i_i_y? = odds.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ODDS mean?
ODDS noun- (diminutive) An odd number.
- Something left over, not forming part of a set.
- The ratio of the probability of an event happening to that of it not happening.
- The ratio of winnings to stake in betting situations.