The most common and most likely answer to this crossword clue is the 7 letter word SEDATES
S
E
D
A
T
E
S
More clues leading to the result SEDATES
- Relaxes partners after endless sex
- Relaxes with girlfriends from Surrey?
- Sober son administers drugs
- Puts out peel of sizable fruit
- She’s beginning to head off to keep appointment and calms down
- Repositioned as steed relaxes
- Analysed a test-market stocking drugs
- Calms down poorly seated viewers at last
- Observes nurses pinch returned drugs
- Put up notices, taking a small amount of drugs
Buddy explains!

The straight part
We know that "Pacifies" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case pacifies = sedates.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does SEDATES mean?
SEDATES verb- To calm or put (a person) to sleep using a sedative drug.
- To make tranquil.