Cryptic crossword clue
Page inserted in Paradise Lost — second goes missing 10

The most common and most likely answer to this crossword clue is the 10 letter word DISAPPEARS

I've seen this crossword clue in The Daily Telegraph
D
I
S
A
P
P
E
A
R
S

Buddy explains!

The straight part
We know that "goes missing" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case goes missing = disappears.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DISAPPEARS mean?

DISAPPEARS verb
  1. To vanish.
  2. To make vanish; especially, to abduct and murder surreptitiously for political reasons.
  3. To go away; to become lost.

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