Cryptic crossword clue
Pain at its worst, therefore lie down 6

The most common and most likely answer to this crossword clue is the 6 letter word SOREST

I've seen this crossword clue in Financial Times
S
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R
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S
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Buddy explains!

The straight part
We know that "Pain at its worst" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case pain at its worst = sorest.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SOREST mean?

SOREST adjective
  1. Causing pain or discomfort; painfully sensitive.
  2. Sensitive; tender; easily pained, grieved, or vexed; very susceptible of irritation.
  3. Dire; distressing.
  4. Feeling animosity towards someone; annoyed or angered.
  5. Criminal; wrong; evil.

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