The most common and most likely answer to this crossword clue is the 10 letter word IRRITATION
I've seen this crossword clue in The Guardian
I
R
R
I
T
A
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O
N
More clues leading to the result IRRITATION
- Drag one behind reindeer’s tail, helping to secure it
- Pain initiator overcome with resistance
- Drag in traitor involved with one
- Watering cans good for surface tension, which is a nuisance
- Anger from one clergyman given unopened summons
- Bother single Romeo having sex in allotment
- It could bring one up to scratch
- Pique irregular case with sex in short supply
- Trouble, fiery occasionally, with sex in part
- I start to raise it in allotment, producing annoyance
Buddy explains!
The straight part
We know that "Pain" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case pain = irritation.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does IRRITATION mean?
IRRITATION noun- The act of irritating or annoying
- The state of being irritated
- The act of exciting, or the condition of being excited to action, by stimulation; -- as, the condition of an organ of sense, when its nerve is affected by some external body; especially, the act of exciting muscle fibers to contraction, by artificial stimulation; as, the irritation of a motor nerve by electricity; also, the condition of a muscle and nerve, under such stimulation.
- A condition of morbid excitability or oversensitiveness of an organ or part of the body; a state in which the application of ordinary stimuli produces pain or excessive or vitiated action.