Cryptic crossword clue
Pain relief when casing seal is broken 10

The most common and most likely answer to this crossword clue is the 10 letter word ANALGESICS

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Buddy explains!

The straight part
We know that "Pain relief" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case pain relief = analgesics.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ANALGESICS mean?

ANALGESICS noun
  1. Any medicine, such as aspirin, that reduces pain, especially without inducing a loss of other sensation. (Contrast anesthetic.)

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