The most common and most likely answer to this crossword clue is the 7 letter word TORTURE
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More clues leading to the result TORTURE
- Tutor upset about abuse
- Rack pulled apart, vertical groove in it
- It may result in a painful admission
- Wrong treatment — not the first to cause extreme suffering
- Anguish of French priest caught out after a wrongful act
- Anguish brought by run going up over river
- Tutor prepared scripture class for martyr
- Run up river as punishment
- Not up to herniation – it’s agony
- Jog back alongside river? It’ll hurt!
Buddy explains!

The straight part
We know that "Pain" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case pain = torture.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does TORTURE mean?
TORTURE noun- Intentional causing of somebody's experiencing agony
- The "suffering of the heart" imposed by one on another, as in personal relationships
- (often as "absolute torture") stage fright, severe embarrassment
- To intentionally inflict severe pain or suffering on (someone).