Cryptic crossword clue
Painful sore makes one get agitated 4

The most common and most likely answer to this crossword clue is the 4 letter word BOIL

I've seen this crossword clue in The Times
B
O
I
L

Buddy explains!

The straight part
We know that "Painful sore/get agitated" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case painful sore/get agitated = boil.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does BOIL mean?

BOIL noun
  1. A localized accumulation of pus in the skin, resulting from infection.
BOIL noun
  1. The point at which fluid begins to change to a vapour.
  2. A dish of boiled food, especially based on seafood.
  3. The collective noun for a group of hawks.
BOIL verb
  1. (of liquids) To heat to the point where it begins to turn into a gas.
  2. To cook in boiling water.
  3. (of liquids) To begin to turn into a gas, seethe.
  4. To bring to a boil, to heat so as to cause the contents to boil.
  5. (used only in progressive tenses, of weather) To be uncomfortably hot.
  6. (used only in progressive tenses) To feel uncomfortably hot.
  7. To form, or separate, by boiling or evaporation.
  8. To steep or soak in warm water.
  9. To be agitated like boiling water; to bubble; to effervesce.
  10. To be moved or excited with passion; to be hot or fervid.

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