Cryptic crossword clue
Painful start after he replaces one from which position? 6

The most common and most likely answer to this crossword clue is the 6 letter word WHENCE

I've seen this crossword clue in Independent
W
H
E
N
C
E

Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does WHENCE mean?

WHENCE adverb
  1. From where; from which place or source.
WHENCE conjunction
  1. Used for introducing the result of a fact that has just been stated.

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