The most common and most likely answer to this crossword clue is the 5 letter word DUOMO
I've seen this crossword clue in The Times
D
U
O
M
O
More clues leading to the result DUOMO
- Pair with little time for cathedral
- Large church found by couple on way to work
- Brace secures centre of Rome cathedral
- Couple tick
- There’s a couple on second biggest church in Florence
- Pair join medic in Italian cathedral
- Couple’s short time in cathedral
- Two people taking month for construction in Italy
- Old married couple sitting outside cathedral
Buddy explains!
The straight part
We know that "cathedra" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case cathedra = duomo.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does DUOMO mean?
DUOMO noun- A cathedral, especially one in Italy.