Cryptic crossword clue
Panama perhaps will welcome one American interruption 6

The most common and most likely answer to this crossword clue is the 6 letter word HIATUS

I've seen this crossword clue in The Daily Telegraph
H
I
A
T
U
S


Buddy explains!

The straight part
We know that "interruption" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case interruption = hiatus.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HIATUS mean?

HIATUS noun
  1. A gap in a series, making it incomplete.
  2. An interruption, break or pause.
  3. An unexpected break from work.
  4. A gap in geological strata.
  5. An opening in an organ.
  6. A syllable break between two vowels, without an intervening consonant. (Compare diphthong.)

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