The most common and most likely answer to this crossword clue is the 12 letter word MASSHYSTERIA
M
A
S
S
H
Y
S
T
E
R
I
A
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.