The most common and most likely answer to this crossword clue is the 4 letter word ASPS
I've seen this crossword clue in The Times
A
S
P
S
More clues leading to the result ASPS
- Pants, no good for snakes
- Deadly reptiles decapitated insects
- Venomous lot: privileged Americans dismissive of women
- Stinging insects, with tip of wings clipped, remain poisonous creatures
- Primarily alarming, serpentine poisonous slitherers?
- Snakes, like heartless politicians
- The Origins of a Species popularised savage serpents
- Trees spring back around south
- Wife avoiding insects and snakes
- Stakes [sNakes] small in backward resort
Buddy explains!

The straight part
We know that "snakes" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case snakes = asps.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ASPS mean?
ASPS noun- A water snake.
- A venomous viper native to southwestern Europe (Vipera aspis).
- The Egyptian cobra (Naja haje)
- A type of European fish (Aspius aspius).
- The aspen tree.