The most common and most likely answer to this crossword clue is the 6 letter word SQUIRM
I've seen this crossword clue in The Times
S
Q
U
I
R
M
More clues leading to the result SQUIRM
- Parisian who stops married woman returning to worm
- Shift uncomfortably large sums of money after US lawyer loses case
- Country gentleman setting aside a little earth for minute worm
- Wriggle as old attendant finishes early mass
- Briefly escort maiden and feel awkward
- Little chap given money for treat’s beginning to fidget
- 7 Ageless quagmires shake and move with a wriggling motion
Buddy explains!

The straight part
We know that "to worm" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case to worm = squirm.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does SQUIRM mean?
SQUIRM noun- A twisting, snakelike movement of the body.
- To twist one's body with snakelike motions.
- To twist in discomfort, especially from shame or embarrassment.
- To evade a question, an interviewer etc.