Cryptic crossword clue
Part in ‘Nemesis’ let slip lack of substance 9

The most common and most likely answer to this crossword clue is the 9 letter word EMPTINESS

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Buddy explains!

The straight part
We know that "lack of substance" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case lack of substance = emptiness.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EMPTINESS mean?

EMPTINESS noun
  1. The state or feeling of being empty.

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