The most common and most likely answer to this crossword clue is the 8 letter word OCTUPLET
I've seen this crossword clue in The Guardian
O
C
T
U
P
L
E
T
More clues leading to the result OCTUPLET
Buddy explains!

The straight part
We know that "Part of big issue to be raised" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case part of big issue to be raised = octuplet.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does OCTUPLET mean?
OCTUPLET noun- A multiplet of eight related things.
- Any of a group of eight babies born from the same mother during the same birth.
- A group of eight notes to be played in the time of six.