Cryptic crossword clue
Part of brain disease rarely concealed by a stroke 8

The most common and most likely answer to this crossword clue is the 8 letter word APPESTAT

I've seen this crossword clue in Independent
A
P
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Buddy explains!

The straight part
We know that "part of brain" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case part of brain = appestat.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does APPESTAT mean?

APPESTAT noun
  1. The area of the brain (possibly in the hypothalamus) supposed to control appetite and regulate food intake

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