The most common and most likely answer to this crossword clue is the 4 plus 4 letter word EAST SIDE
I've seen this crossword clue in The Guardian
E
A
S
T
S
I
D
E
More clues leading to the result EAST SIDE
- European sounded weary when picked up on a street here in NY?
- Start of tropical disease outbreak in part of Manhattan
- Manhattan district steadies corruption
- English players cross a street somewhere in New York
- Disturbed sadist surrounded by drugs somewhere in Manhattan
- Part of city street crossed by European on main track
- Ultimately airplane disaster almost ruined part of New York
- Removal of intro badly disorientates new part of Manhattan
- Finally, the disaster destroyed a section of Manhattan
- Steadies troubled part of Manhattan
Buddy explains!

The straight part
We know that "Part of city" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case part of city = east side.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.