Cryptic crossword clue
Part of Manhattan, as far as two quarters will get you 6

The most common and most likely answer to this crossword clue is the 6 letter word UPTOWN

I've seen this crossword clue in The Guardian
U
P
T
O
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Buddy explains!

The straight part
We know that "Part of Manhattan" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case part of manhattan = uptown.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does UPTOWN mean?

UPTOWN noun
  1. The residential part of a city, away from the commercial center
UPTOWN adjective
  1. In the upper part of a town.
  2. (by extension) Of or relating to an affluent area or population.
UPTOWN adverb
  1. To or in the upper part of a town.

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