The most common and most likely answer to this crossword clue is the 5 letter word OMAHA
I've seen this crossword clue in The Guardian
O
M
A
H
A
More clues leading to the result OMAHA
- A meat and egg combination served up in US city
- Bit of a pig to get around in outskirts of Oklahoma City
- Round motorway, I see US city
- A bad actor with Oscar from South American city
- City given prestigious award — I’m surprised!
- US city has royal award, I see
- Spiritual icon I see in US city
- US city in Oklahoma? Hardly
- Beach where maiden wears nothing, I see!
- US city and Tyrone town with no golf area
Buddy explains!
The straight part
We know that "somewhere on the Missouri" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case somewhere on the missouri = omaha.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.