Cryptic crossword clue
Part of ugly sister destroying process 5

The most common and most likely answer to this crossword clue is the 5 letter word LYSIS

I've seen this crossword clue in The Guardian
L
Y
S
I
S

Buddy explains!

The straight part
We know that "destroying process" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case destroying process = lysis.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does LYSIS mean?

LYSIS noun
  1. A gradual recovery from disease (opposed to crisis).
  2. The disintegration or destruction of cells
  3. The breakdown of molecules into constituent molecules
  4. A plinth or step above the cornice of the podium in an ancient temple.

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