Cryptic crossword clue
Particle, larger than normal, has it in for most common of neutrinos 8

The most common and most likely answer to this crossword clue is the 8 letter word POSITRON

P
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T
R
O
N


Buddy explains!

The straight part
We know that "Particle" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case particle = positron.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does POSITRON mean?

POSITRON noun
  1. The antimatter equivalent of an electron, having the same mass but a positive charge

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