Cryptic crossword clue
Party 2s, a nervous lot? 9

The most common and most likely answer to this crossword clue is the 9 letter word GANGLIONS

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "a nervous lot" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case a nervous lot = ganglions.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GANGLIONS mean?

GANGLIONS noun
  1. An encapsulated collection of nerve-cell bodies, located outside the brain and spinal cord.
  2. Any of certain masses of gray matter in the brain, as the basal ganglia.
  3. (by extension) A centre of intellectual or industrial force, activity, etc.
  4. A cystic tumour on a tendon sheath or joint capsule; a ganglion cyst.

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