The most common and most likely answer to this crossword clue is the 2 plus 3 plus 2 letter word NO CAN DO
I've seen this crossword clue in The Times
N
O
C
A
N
D
O
More clues leading to the result NO CAN DO
- Party enforcing six-pack ban? It's not possible
- Lack of honesty old city avoided? That’s not possible
- Old knight upset a name in Conservative party? It's not possible
- Lacking a drink before party? Impossible!
- Recalled old swindle by geneticists? Impossible!
- Agreement to embrace John? Nothing is impossible
- Knock fans’ idol, showing guts? Impossible!
- Impossible bottle party?
- New supermarket across Norway impossible, I’m afraid
- Unable to help Donna & co, regrettably
Buddy explains!
The straight part
We know that "It's not possible" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case it's not possible = no can do.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.