Cryptic crossword clue
Passed over hard liquor when depressed

The most common and most likely answer to this crossword clue is the 10 letter word DISPIRITED

I've seen this crossword clue in The Guardian
D
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P
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D

Buddy explains!

The straight part
We know that "depressed" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case depressed = dispirited.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DISPIRITED mean?

DISPIRITED verb
  1. To lower the morale of; to make despondent; to dishearten.
DISPIRITED adjective
  1. Without energy, gusto or drive, enervated, without the will to accomplish, disheartened.

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